Novel spiro-lactam compounds, process and uses thereof
AssigneesUniversidade De Coimbra, Faculdade De Farmacia Da Universidade De Lisboa, Egas Moniz—Cooperativa De Ensino Superior, Crl, Instituto De Medicina Molecular
InventorsTeresa Margarida VASCONCELOS DIAS DE PINHO E MELO, Bruna C. SUZANO SANTOS, Inês BÁRTOLO, Rui Miguel PRUDÊNCIO PIGNATELLI, Nuno Eduardo MOURA DOS SANTOS DA COSTA TAVEIRA
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to a new class of antimicrobial agents. In particular, this disclosure provides the identification and characterization of novel spiro-lactam compounds as anti-HIV/AIDS and anti-malarial agents. Furthermore, this disclosure also provides the preparation of spiro-β-penicillanic acids, which proved to be potent inhibitors of HIV.
Claims31
A compound of formula I;
- wherein
- R1, R2 and R3 are independently selected from each other;
- R1 is H or CHPh2;
- R2 is a lactam ring;
- and
- R3 is a heterocyclic ring or a carbocyclic ring.
(canceled)
(canceled)
(canceled)
A compound of formula I;
- wherein
- R1, R2 and R3 are independently selected from each other;
- R1 is H or CHPh2;
- R2 is a lactam ring;
- and
- R3 is a heterocyclic ring or a carbocyclic ring,
- with the proviso that the following compounds are excluded:
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.