Multiple analyte ion source
AssigneePerkinElmer Health Sciences Canada, Inc.
InventorsFrenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Abstract
A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.
Claims23
A device for providing analyte to a mass analyzer, the device comprising:
- a substrate comprising a plurality of wells therein at predetermined locations, each of the plurality of wells of the substrate configured to receive and contain an analyte without mixing with analytes in other of the wells, wherein each of the wells comprises a well exit to allow analyte to exit therefrom;
- and
- a channel fluidically coupled to at least one of the well exits, wherein the channel is configured to guide analyte ions exiting therefrom to the mass analyzer.
17-19. (canceled)
21-23. (canceled)
A method for providing analyte to a mass analyzer, the method comprising:
- eluting fractions of analyte from a liquid source;
- directing each of the eluted fractions to one of a plurality of individual wells of a substrate, wherein the substrate comprises a plurality of the individual wells therein at predetermined locations, each of the wells capable of containing an analyte without mixing with analytes in other of the wells, wherein each of the wells comprises a well exit to allow analyte to exit therefrom;
- and
- interconnecting a channel in flow communication with at least one of the well exits to guide selected analyte ions exiting therefrom to the mass analyzer.
A fraction collector system comprising a substrate comprising a plurality of sample wells therein at predetermined locations, wherein each of the sample wells comprises an opening extending from a top surface of the substrate and is capable of containing a flow of analyte sample without mixing with analyte in other of the sample wells, and wherein each of the sample wells comprises an exit on a bottom surface of the substrate.
27-29. (canceled)
Dependencies are inferred from the claim text.