System and method for estimating a quantity of interest based on an image of a histological section

Abstract

A method for determining a quantity of interest related to the density of organic tissue starts with a digital representation of a histological image of the tissue. The digital representation is converted to a binary image, to discriminate pixels that represent tissue of interest in the image. A box filter is applied to values of the pixels of interest to obtain a tissue density value for each pixel of interest. A quantity of interest is computed, based upon the tissue density values for the pixels of interest. A tangible representation of the computed quantity of interest, such as a numerical value, a graph, or a color representation, is displayed or otherwise presented via an interface. Prior to forming the digital representation, the tissue can be stained to distinguish particular types of tissue for removal or enhancement in the determination of the quantity of interest.

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