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US 2020/0348322 A1Published application
Methods and apparatus for bead manipulation in a tip of a liquid handler
AssigneeAndrew Alliance S.A.
InventorGiorgio Horak
Life of this patent
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Abstract
The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.
Claims20
A method for separating beads, comprising:
- providing a liquid containing beads into a volume, wherein at least some beads have magnetic properties;
- applying a magnetic field to at least a portion of the volume;
- varying the magnetic field applied onto the volume over time, wherein one or more magnetic field profiles provide an optimized gradient of the magnetic field along the vertical axis of the volume;
- and
- separating the magnetic beads from the liquid into a bead cluster by action of the optimized gradient of the magnetic field.
2 more elements
An apparatus for separating beads suspended in liquid, comprising:
- one or more magnets external to a volume, wherein a magnetic field produced by the one or more magnets is configured to be modulated in order to apply a varying magnetic field to the volume for the purpose of separating the beads from the liquid, wherein one or more magnetic field profiles produced by the one or more magnets provide an optimized gradient of the magnetic field along the vertical axis of the volume.
Dependencies are inferred from the claim text.