Methods for evaluating and improving cognitive function
AssigneesThe University of Melbourne, The Florey Institute of Neuroscience and Mental Health
InventorsWah Chin BOON, Ute ROESSNER, Thusitha Wasantha Thilaka PASINGHE, Enie LEI
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Abstract
The present invention generally relates to method for evaluating and improving cognitive function in a subject. In particular, the invention generally relates to methods for evaluating cognitive function in a subject by determining the level of cholesteryl esters in a subject, and to improving cognitive function in a subject comprising the administration of cholesteryl oleate, or analogues thereof.
Claims51
A method of evaluating cognitive function in a subject, the method comprising determining the level of cholesteryl oleate (CE 18:1) in the subject or a biological sample obtained therefrom, wherein a lower level of cholesteryl oleate is indicative of a greater level of impaired cognitive function.
A method of evaluating cognitive function in a subject, the method comprising determining the level of cholesteryl palmitate (CE 16:0) and/or cholesteryl palmitoleate (CE 16:1) in the subject or a biological sample obtained therefrom, wherein a higher level of cholesteryl palmitate and/or cholesteryl palmitoleate is indicative of a greater level of impaired cognitive function.
A method of improving cognitive function in a subject, the method comprising administering to the subject an effective amount of cholesteryl oleate, or an analogue thereof.
Cholesteryl oleate, or an analogue thereof, for use in improving cognitive function in a subject.
Use of cholesteryl oleate, or an analogue thereof, for the manufacture of a medicament or nutraceutical for improving cognitive function in a subject.
A pharmaceutical or nutraceutical composition comprising cholesteryl oleate, or an analogue thereof, and a pharmaceutically or nutraceutically acceptable excipient, wherein the cholesteryl oleate is present in an amount effective for improving cognitive function in a subject.
A method of identifying a therapeutically effective compound for improving cognitive function in a subject, comprising administering an amount of a cholesteryl ester, or an analogue thereof, to an animal to determine if the animal has improved cognitive function.
Dependencies are inferred from the claim text.