Systems and methods for diagnosing and treating chronic organ rejection
AssigneeDignity Health
InventorThalachallour Mohanakumar
Life of this patent
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Abstract
Embodiments of the invention provide a method for diagnosing and treating chronic organ rejection in a subject that has previously received an allographic organ transplant. The method may include (i) receiving a sample from the subject, wherein the subject does not yet experience symptoms of chronic organ rejection and (ii) measuring expression of at least one marker within the sample. In some aspects, the method may also include (iii) treating the subject with at least one therapeutic methodology when the expression of the at least one marker is increased compared to expression of the marker in a control sample.
Claims19
A method of detecting and treating chronic organ rejection in a subject, the subject having previously received an allographic organ transplant, the method comprising the steps of:
- receiving a sample from the subject, wherein the subject does not yet experience symptoms of chronic organ rejection;
- measuring expression of at least one marker within the sample;
- treating the subject with at least one therapeutic methodology when the expression of the at least one marker is increased compared to expression of the marker in a control sample.
A method of detecting and treating bronchiolitis obliterans syndrome (BOS) in a subject, the subject having previously received an allographic lung transplant, the method comprising the steps of:
- receiving a liquid sample from the subject, wherein the subject does not yet experience symptoms of BOS;
- isolating exosomes from the liquid sample;
- measuring expression of at least one marker within the exosomes;
- treating the subject with at least one therapeutic methodology when the expression of the at least one marker is increased compared to expression of the marker in a control sample.
Dependencies are inferred from the claim text.