GPCRs in Cancer-Associated Fibroblasts
AssigneeThe Regents of the University of California
InventorsPaul A. Insel, Andrew M. Lowy, Shu Wiley, Randall French, Krishna Sriram
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Abstract
Methods and biomarker panels for detecting and treating pancreatic disease, including pancreatic cancer, are provided in association with determining and inhibiting expression levels of certain GPCRs, including GPR68, in particular in pancreatic cancer associated fibroblasts.
Claims17
A method for detecting and treating a pancreatic disease in a patient comprising:
- obtaining a biological sample from the patient;
- detecting expression level of one or more GPCR in the sample;
- determining that the expression level of the one or more GPCR is greater than in a normal patient sample;
- and
- treating the patient for the pancreatic disease.
A biomarker panel for detecting pancreatic cancer comprising or consisting of at least 3, 5, 10, 15, 20, 25, or 30 GPCRs as shown in Table 3.
A biomarker panel for detecting pancreatic cancer consisting of GPR68 and at least one other upregulated GPCR as shown in Table 3.
A method for detecting pancreatic disease in a patient comprising:
- obtaining a biological sample from the patient;
- detecting expression level of one or more GPCR in the sample;
- and
- determining that the expression level of the one or more GPCR is greater than in a normal patient sample, thereby detecting pancreatic disease in the patient.
Dependencies are inferred from the claim text.