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US 2020/0348291 A1Published application
Near infrared fluorescent biosensors for steroid hormones
AssigneeMassachusetts Institute of Technology
InventorsMichael Strano, Michael Lee, Naveed Bakh, Song Wang
Life of this patent
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Abstract
Corona Phase Molecular Recognition (CoPhMoRe) utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.
Claims24
A composition, comprising:
- a complex, wherein the complex includes:
- a nanostructure;
- and
- a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure, wherein the polymer is a heteropolymer including a hydrophobic region and a hydrophilic region and the polymer includes a template moiety;
- and
- a selective binding site associated with the complex, the selectivity of the selective binding site being dependent on the template moiety.
3 more elements
The composition of claim 8, wherein the template moiety includes a steroid moiety.
A method of making a composition including:
- templating a composition that selective binds an analyte.
Dependencies are inferred from the claim text.