A method and a system for analysis of cardiomyocyte function

A device for analysis of cardiomyocyte function, said device comprising:

• readout circuitry for reading out electrical signals from a substrate comprising a microelectrode array in contact with cardiomyocytes on a cell culturing surface of the substrate;
• an image sensor arranged such that the cell culturing surface of the substrate is facing the image sensor when the substrate is arranged to allow the readout circuitry to read out the electrical signals, the image sensor being configured to, simultaneously with reading out of electrical signals by the readout circuitry, acquiring a sequence of images of the cardiomyocytes on the cell culturing surface, wherein each image in the sequence of images is acquired by detecting light wavefront information of reflected light, the light wavefront information forming an interference pattern between diffracted light from the cardiomyocytes and undiffracted light, and digitally calculating image information based on the detected light wavefront information;
• a processing unit -configured to receive the electrical signals from the readout circuitry and image information from the image sensor, said processing unit being further configured to determine an electrical representation relating to an intracellular and/or extracellular action potential, and/or an impedimetric electrical image of a cardiomyocyte based on the recorded electrical signals, and to determine a contractile representation relating to cellular deformation during contractility action of a group of cardiomyocytes based on the acquired sequence of images, wherein the electrical representation and the contractile representation apply to a common period of time.