Sensors, systems and methods for detecting analytes using same
AssigneeModoc Technologies, LLC
InventorsDavid H. Sierra, Andrew Korey
Life of this patent
Estimating the term…
Abstract
Sensors, as well as systems and methods of using the same are provided. Aspects of the sensors include a piezoelectric base, a plurality of surface-associated compositions that are stably associated with the piezoelectric base, and a plurality of crosslinking compositions that are configured to crosslink one or more surface-associated compositions in the presence of an analyte. The sensors, systems and methods described herein find use in a variety of applications, including the detection of an analyte in a sample.
Claims24
-17. (canceled)
A system for detecting the presence of an analyte in a sample, the system comprising:
- a sensor comprising:
- a piezoelectric base;
- a plurality of surface-associated compositions that are stably associated with the piezoelectric base;
- a plurality of crosslinking compositions that are configured to crosslink one or more surface-associated compositions in the presence of the analytewhen an analyte binds to an analyte binding domain of a crosslinking composition;
- and
- at least one electrode;
- an oscillator circuit that is electrically connected to the at least one electrode and is configured to drive the sensor at one or more frequencies, wherein the oscillator circuit comprises an automatic gain control (AGC) portion;
- a detection unit configured to receive a plurality of data from the oscillator circuit;
- and
- a processor configured to analyze the data received from the oscillator circuit and to detect the presence of the analyte in the sample,
- wherein the sensor, the oscillator circuit, the detection unit, and the processor are formed into a single device.
(canceled)
-55. (canceled)
A method of making a sensor, the method comprising:
- depositing a plurality of surface-associated compositions on a piezoelectric base, wherein the plurality of surface-associated compositions are adapted to stably associate with the piezoelectric base;
- and
- depositing a plurality of crosslinking compositions on top of the surface-associated compositions, wherein the crosslinking compositions are configured to crosslink one or more of the surface-associated compositions when an analyte binds to an analyte binding domain of a crosslinking composition.
-73. (canceled)
Dependencies are inferred from the claim text.