Methods for treating polymicrobial infections
AssigneeCAP Diagnostics, LLC, dba Pathnostics
InventorsDavid A. Baunoch, Miguel F.R. Penaranda, Michael L. Opel, Maher Badir, Natalie Luke
Life of this patent
Estimating the term…
Abstract
Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.
Claims13
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of E. faecalis and E. coli, the method comprising:
- a. detecting the presence of both E. faecalis and E. coli in a source of the infection obtained from the patient;
- and
- b. administering to the patient one or a combination of antimicrobials selected from:
- amoxicillin/clavulanate, ampicillin/sulbactam, levofloxacin, meropenem, and tetracycline;
- wherein E. faecalis and E. coli together have a decreased odds of resistance to amoxicillin/clavulanate, ampicillin/sulbactam, levofloxacin, meropenem, and tetracycline, thus amoxicillin/clavulanate, ampicillin/sulbactam, levofloxacin, meropenem, and tetracycline are effective for killing or inhibiting growth of E. faecalis and E. coli to treat the polymicrobial infection.
3-9. (canceled)
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of E. coli and S. agalactiae, the method comprising:
- a. detecting the presence of both E. coli and S. agalactiae in a source of the infection obtained from the patient;
- and
- b. administering to the patient one or a combination of antimicrobials selected from:
- ampicillin, cefepime, ceftazidime, ceftriaxone, ciprofloxacin, levofloxacin, tetracycline, and TMP/sulfamethoxazole;
- wherein E. coli and S. agalactiae together have a decreased odds of resistance to ampicillin, cefepime, ceftazidime, ceftriaxone, ciprofloxacin, levofloxacin, tetracycline, and TMP/sulfamethoxazole, thus ampicillin, cefepime, ceftazidime, ceftriaxone, ciprofloxacin, levofloxacin, tetracycline, and TMP/sulfamethoxazole are effective for killing or inhibiting growth of E. coli and S. agalactiae to treat the polymicrobial infection.
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of E. coli and Coagulase-negative Staphylococcus (CoNS), the method comprising:
- a. detecting the presence of both E. coli and CoNS in a source of the infection obtained from the patient;
- and
- b. administering to the patient one or a combination of antimicrobials selected from:
- ampicillin, ceftriaxone, tetracycline, and TMP/sulfamethoxazole;
- wherein E. coli and CoNS together have a decreased odds of resistance to ampicillin, ceftriaxone, tetracycline, and TMP/sulfamethoxazole, thus ampicillin, ceftriaxone, tetracycline, and TMP/sulfamethoxazole are effective for killing or inhibiting growth of E. coli and CoNS to treat the polymicrobial infection.
(canceled)
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of K. pneumoniae and Coagulase-negative Staphylococcus (CoNS), the method comprising:
- a. detecting the presence of both K. pneumoniae and CoNS in a source of the infection obtained from the patient;
- and
- b. administering to the patient one or a combination of antimicrobials selected from:
- ampicillin, ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, and TMP/sulfamethoxazole;
- wherein K. pneumoniae and CoNS together have a decreased odds of resistance to ampicillin, ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, and TMP/sulfamethoxazole, thus ampicillin, ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, and TMP/sulfamethoxazole are effective for killing or inhibiting growth of K. pneumoniae and CoNS to treat the polymicrobial infection.
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of S. agalactiae and Coagulase-negative Staphylococcus (CoNS), the method comprising:
- a. detecting the presence of both S. agalactiae and CoNS in a source of the infection obtained from the patient;
- and
- b. administering to the patient one or a combination of antimicrobials selected from:
- ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, tetracycline, TMP/sulfamethoxazole, and vancomycin;
- wherein S. agalactiae and CoNS together have a decreased odds of resistance to ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, tetracycline, TMP/sulfamethoxazole, and vancomycin, thus ceftriaxone, ciprofloxacin, levofloxacin, gentamicin, tetracycline, TMP/sulfamethoxazole, and vancomycin are effective for killing or inhibiting growth of S. agalactiae and CoNS to treat the polymicrobial infection.
15-22. (canceled)
Dependencies are inferred from the claim text.