Methods and system of human hemogenic reprograming
AssigneeIcahn School of Medicine at Mount Sinai
InventorsKateri A. Moore, Ihor R. Lemischka, Michael G. Daniel
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Abstract
This disclosure provides a method for programming human somatic cells into hematopoietic stem cells (HSCs). The method includes inducing expression of the 3GF reprogramming transcription factor cocktail, including GATA2, GFI1B, GFI1, and FOS transcription factors, in human somatic cells. Further, this disclosure also demonstrates co-culturing HSCs with AFT024 stroma cells results in more functional cells, both qualitatively and quantitatively.
Claims18
A method for programming a human somatic cell into a hematopoietic stem cell, the method comprising introducing into the human somatic cell a combination of transcription factors, wherein the combination comprises GATA binding protein 2 (GATA2), growth factor independent 1B (GFI1B), growth factor independent 1 (GFI1), and FBJ osteosarcoma oncogene (FOS).
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