System and method for extracting ethanol from a fermentation broth

A method of making an organic compound by fermentation,

• comprising;
• fermenting a carbohydrate source with a fermentation organism that makes the organic compound in a fermentation vessel forming a fermentation broth comprising suspended solids and the organic compound;
• passing a portion of the fermentation broth to a solids separation means in fluid connection with the fermentation vessel to separate suspended solids from the fermentation broth forming a clarified broth;
• passing a flow of the clarified broth through a membrane module comprising a selectively permeable membrane that permits passage of more of the organic compound relative to water across the membrane in a first flow direction tangential to the surface of the membrane:
• passing a flow of organic extraction solvent through the membrane module to contact the membrane on a side opposite the side receiving the flow of clarified broth in a second flow direction tangential to the membrane that is countercurrent or cross current relative to the flow of clarified broth in the first direction while maintaining a positive pressure on the flow of clarified broth relative to the flow of extraction solvent in the membrane module, thereby forming a solvent extract containing a portion of the organic compound and a solvent extracted broth containing a portion of the organic solvent;
• passing the solvent-extracted broth from the membrane module to a decanter to separate the solvent extracted broth into a solvent phase comprised of the organic solvent and an aqueous phase, wherein passing the solvent extracted broth to the decanter includes slowing the rate of flow of the solvent extracted broth from the membrane module to thereby enhance separation of into the solvent phase and the aqueous phase in the decanter;
• passing the aqueous phase from the decanter back to the fermentation vessel;
• passing the solvent extract from the membrane module to a separation means to separate the organic compound from the extraction solvent;
• and
• collecting the organic compound.