Cellular behaviour monitoring device and method for monitoring changes in cellular behaviour

A cellular behaviour monitoring device for monitoring changes in behaviour of cells contained in a sample, the cellular behaviour monitoring device comprising:

• a well plate having a first surface, a second surface opposite to the first surface, and at least one sample receiving well recessed from the first surface of the well plate;
• a filter membrane extending across the first surface of the well plate and hermetically covering the at least one sample receiving well, the filter membrane having a plurality of pores extending through the filter membrane, the plurality of pores having a dimension exceeding a nutrient dimension and being smaller than a cell dimension;
• and
• an electrode layer extending across the filter membrane, the electrode layer having a substrate and a plurality of behaviour monitoring electrodes spaced-apart from one another in a region of the substrate, the region being aligned with the at least one sample receiving well, the electrode layer having a plurality of apertures distributed across the region, the plurality of apertures having a dimension exceeding the dimension of the plurality of pores, at least some of the plurality of pores being aligned with at least some of the plurality of apertures to allow fluid communication therebetween.