Macrocarriers for cell growth in bioreactors
OwnerChanyong Brian Lee, Maximilian Lee +1inventors
InventorsChanyong Brian Lee, Maximilian Lee, Sunghoon Jung
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Abstract
Macrocarriers with flat surface areas which can be easily suspended in liquid using low power input will improve cell attachment and growth in bioreactors. Such macrocarriers can be consistently manufactured to exact size specifications, which can significantly reduce the risk of contamination by small size particulates. The macrocarriers may be flat discs or squares with central bumps on each face to prevent stacking. The macrocarriers may also have outward curved wings from two or four sides to facilitate distribution in moving solution.
Claims22
A macrocarrier for a cell culture growth process, comprising:
- a molded plate-like body having opposed faces separated by a peripheral edge, the body having a thickness T that is between about 0.4-10% of the minimum dimension from one side of the peripheral edge to the other, the body defining a vertical axis perpendicular to the thickness and further including a vertical bump projecting from each face to prevent two macrocarriers from contacting one another across entire adjacent faces.
A macrocarrier for a cell culture growth process, comprising:
- a molded plate-like body having opposed faces separated by a peripheral edge and a thickness T across the opposed faces, the body defining a vertical axis perpendicular to the thickness and further including a vertical bump projecting from each face to prevent two macrocarriers from contacting one another across entire adjacent faces, the body further including at least two wings formed at diametrically opposite sides of the peripheral edge that curve in the same direction from the body.
Dependencies are inferred from the claim text.