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US 2020/0347267 A1Published application
Chemistries for Biocompatible Additive Nanolithography
AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy
InventorsDavid A. Kidwell, Thomas O'Shaughnessy
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Abstract
A mixed acrylate-siloxane polymer can be used to create three-dimensional (3D) structures of arbitrary shape via nanolithography. Treatment of such structures with amine (such as diamine) makes them permissive for neuronal cell adhesion and growth without need of additional modification such as poly-lysine (D or L) nor laminin.
Claims16
A structure for cellular growth comprising:
- a substrate;
- and
- an acrylate-containing polymer attached thereto and in a state of having been functionalized using an amine so as to provide free amine groups on the polymer,
- wherein the structure is suitable for the growth of mammalian cells thereon.
1 more element
A structure for cellular growth comprising:
- a glass substrate;
- and
- an acrylate-containing polymer attached thereto and in a state of having been functionalized using a diamine so as to provide free amine groups on the polymer,
- wherein the structure is suitable for the growth of mammalian cells thereon.
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A method of preparing a structure for cell culture, the method comprising:
- providing an acrylate polymer attached to a substrate,
- optionally treating the polymer to remove residual solvent and/or monomer;
- and then
- performing Michael addition of amine with free acrylate groups on the polymer.
1 more element
Dependencies are inferred from the claim text.