BINDING UNIT TARGETING FIBROBLAST ACTIVATION PROTEIN alpha AND APPLICATION THEREOF
AssigneesCarsgen Therapeutics Co., Ltd., Shanghai Cancer Institute
InventorsZonghai LI, Peng WANG
Life of this patent
Estimating the term…
Abstract
A binding unit that specifically binds to fibroblast activation protein α (FAPα), a polynucleotide that encodes the binding unit, a vector that comprises the polynucleotide and a host cell, a method for use in producing the antigen-binding unit and a method for treating a disease by using the FAPα-specific binding unit; the binding unit that specifically binds to FAPα may efficiently bind to tumor cells that express FAPα, and immune effector cells comprising the binding unit exhibit significant killing capabilities against tumor cells that express FAP.
Claims37
An antigen binding unit comprising a light chain CDR region and a heavy chain CDR region, the heavy chain CDR comprises HCDR1, HCDR2 and HCDR3, and the light chain CDR region comprises LCDR1, LCDR2 and LCDR3;
- wherein the sequences of the HCDR1, HCDR2 and HCDR3 are independently selected from the group consisting of SEQ ID NO:
- 1-3, 7 and 8, and the sequences of the LCDR1, LCDR2 and LCDR3 are independently selected from the group consisting of SEQ ID NO:
- 4-6, 9 and 10.
An antigen binding unit comprising a light chain CDR region and a heavy chain CDR region, the heavy chain CDR comprises HCDR1, HCDR2 and HCDR3, and the light chain CDR region comprises LCDR1, LCDR2 and LCDR3;
- wherein the HCDR1, HCDR2 and HCDR3 are independently selected from a sequence having at least 80%, preferably at least 85%, more preferably at least 90%, more preferably at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% similarity with any sequence of SEQ ID NO:
- 1-3, 7 and 8, and the LCDR1, LCDR2 and LCDR3 are independently selected from a sequence having at least 80%, preferably at least 85%, more preferably at least 90%, more preferably at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% similarity with any sequence of SEQ ID NO:
- 4-6, 9 and 10.
An antigen binding unit, wherein the antigen binding unit has a sequence having at least 80%, preferably at least 85%, more preferably at least 90%, more preferably at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% similarity with the sequence of the heavy chain variable region as shown in SEQ ID NO:
- 11 or 15 and a sequence having at least 80%, preferably at least 85%, more preferably at least 90%, more preferably at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% similarity with the light chain variable region as shown in SEQ ID NO:
- 13 or 17.
Dependencies are inferred from the claim text.