Sickled beta globin antibodies
Assigneebluebird bio, Inc.
InventorOlivier NEGRE
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Abstract
The invention generally provides improved anti-sickled-globin antibodies and fragments thereof. In particular embodiments, the antibody or antigen binding fragment thereof recognizes the βs, Glu6Val mutation. In various embodiments, the invention provides a conjugate comprising an anti-βs-globin antibody or antigen binding fragment thereof and a detectable label. In particular embodiments, a hybridoma comprising an anti-βs-globin antibody contemplated herein is provided.
Claims10
An anti-βS globin antibody or antigen binding fragment thereof that binds a human βS globin polypeptide, wherein the anti-βS globin antibody or antigen binding fragment thereof comprises a light chain variable region comprising the light chain CDRs (CDRL1-CDRL3) set forth in any one of SEQ ID NOs:
- 1-3 and a heavy chain variable region comprising the heavy chain CDRs (CDRH1-CDRH3) set forth in any one of SEQ ID NOs:
- 4-6.
Dependencies are inferred from the claim text.