4-1bb antibody and preparation method and use thereof
AssigneeShanghai Hyamab Biotech Co., Ltd.
InventorsHeng PAN, Haohan LIU, Yingying GAO, Shaoping HU, Yong LI, Mingming PAN, Tatchi Teddy YANG, Qing DUAN, Lile LIU
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Abstract
Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-γ and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.
Claims10
A heavy chain variable region of an antibody, which comprises the following three complementary determining regions CDRs:
- CDR1 as shown in SEQ ID NO.:
- 2 or SEQ ID NO.:
- 10,
- CDR2 as shown in SEQ ID NO.:
- 3 or SEQ ID NO.:
- 11, and
- CDR3 as shown in SEQ ID NO.:
- 4 or SEQ ID NO.:
- 12,
- wherein, any one of the above-mentioned amino acid sequences further comprises a derivative sequence that is optionally added, deleted, modified, and/or substituted with one amino acid and capable of retaining the binding affinity of 4-1BB.
A light chain variable region of an antibody, which comprises the following three complementary determining region CDRs:
- CDR1′ as shown in SEQ ID NO.:
- 6 or SEQ ID NO.:
- 14,
- CDR2′ as shown in SEQ ID NO.:
- 7 or SEQ ID NO.:
- 15, and
- CDR3′ as shown in SEQ ID NO.:
- 8 or SEQ ID NO.:
- 16.
Dependencies are inferred from the claim text.