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US 2020/0347142 A1Published application
CD123-Binding Polypeptides and Uses Thereof
AssigneeInhibrx, Inc.
InventorsChelsie Macedo, Kyle Jones, William Crago, Andrew Hollands, Milton Ma, John C. Timmer, Brendan P. Eckelman
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Abstract
Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
Claims42
A polypeptide comprising at least one VHH domain that binds CD123 and that comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 33, 42, 3, 7, 11, 15, 19, 23, 36, 39, 45, 48, 51, or 93;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 34, 43, 4, 8, 12, 16, 20, 24, 37, 40, 46, 49, 52, or 94;
- and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 35, 44, 5, 9, 13, 17, 21, 25, 38, 41, 47, 50, 53, or 95.
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Dependencies are inferred from the claim text.