Dendritic cells-targeting vaccine

A recombinant single chain fragment variable (ScFv) binding to DEC-205 of dendritic cells, said ScFv comprising:

• a) a heavy chain variable region comprising CDRH1, CDRH2 and CDRH3, wherein the CDRH1 is selected from a group consisting of SEQ ID NO:
• 11, SEQ ID NO:
• 12, SEQ ID NO:
• 13, and SEQ ID NO:
• 14, CDRH2 is selected from a group consisting of SEQ ID NO:
• 15, SEQ ID NO:
• 16, SEQ ID NO:
• 17, SEQ ID NO:
• 18, SEQ ID NO:
• 19, SEQ ID NO:
• 20, and SEQ ID NO:
• 21, and CDRH3 is selected from a group consisting of SEQ ID NO:
• 22, SEQ ID NO:
• 23, SEQ ID NO:
• 24, SEQ ID NO:
• 25, and SEQ ID NO:
• 26;
• and
• b) a light chain variable region comprising CDRL1, CDRL2 and CDRL3, wherein the CDRL1 is selected from a group consisting of SEQ ID NO:
• 27, SEQ ID NO:
• 28, SEQ ID NO:
• 29, SEQ ID NO:
• 30, and SEQ ID NO:
• 31, CDRL2 is selected from a group consisting of SEQ ID NO:
• 32, SEQ ID NO:
• 33, SEQ ID NO:
• 34, SEQ ID NO:
• 35, SEQ ID NO:
• 36, and SEQ ID NO:
• 37, and CDRL3 is selected from a group consisting of SEQ ID NO:
• 38, SEQ ID NO:
• 39, SEQ ID NO:
• 40, SEQ ID NO:
• 41, SEQ ID NO:
• 42, SEQ ID NO:
• 43, SEQ ID NO:
• 44, and SEQ ID NO:
• 45,
• wherein the heavy chain variable region and the light chain variable region is linked with a linker molecule having amino acid sequence as represented by SEQ ID NO:
• 10.