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US 2020/0347136 A1Published application
Constrained cyclic peptides as inhibitors of the cd2:cd58 protein-protein interaction for treatment of diseases and autoimmune disorders
AssigneeBoard of Supervisors for the University of Louisiana System
InventorSeetharama JOIS
Life of this patent
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Abstract
Chemicals and methods of treating autoimmune/inflammatory diseases, comprising administering to a patient the functional groups of a CD58-targeted peptide grafted onto a cyclic scaffold. An additional embodiment includes wherein one or more of the functional groups of the peptide bind to CD58. An additional embodiment includes wherein the scaffold is chosen from the group of sunflower trypsin inhibitor (SFTI) and theta-defensins.
Claims13
A method of treating an autoimmune or inflammatory disease comprising:
- administering to the patient a pharmacologically effective amount of a therapeutic;
- wherein the therapeutic includes one or more functional groups of a CD58-targeted peptide grafted onto a cyclic scaffold
Dependencies are inferred from the claim text.