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US 2020/0347124 A1Published application
Methods and compositions for treating lung inflammation
AssigneeUniversity of Miami
InventorsRobert W. KEANE, W. Dalton DIETRICH, Juan Pablo De Rivero VACCARI, Helen M. Bramlett, Roberta Brambilla
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Abstract
The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). Also described herein are compositions and methods of use thereof for treating multiple sclerosis.
Claims16
-52. (canceled)
A method of treating inflammation in lungs of a patient in need thereof, the method comprising:
- administering to the patient a composition comprising an antibody or an antibody fragment thereof that binds specifically to Apoptosis-associated Spec-like protein containing a Caspase Activating Recruitment Domain (ASC), wherein the antibody or the antibody fragment comprises a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region amino acid sequence comprises HCDR1 of SEQ ID NO:
- 6, HCDR2 of SEQ ID NO:
- 7 and HCDR3 of SEQ ID NO:
- 8, and wherein the VL region amino acid sequence comprises LCDR1 of SEQ ID NO:
- 12, LCDR2 of SEQ ID NO:
- 13 and LCDR3 of SEQ ID NO:
- 14;
- whereby the inflammation in the lungs of the patient is treated.
5 more elements
Dependencies are inferred from the claim text.