Coll2-1 peptide and its nitrated form as therapeutic targets for osteoarthritis treatment
AssigneesUniversite De Liege, Universite Paris Descartes, Assistance Publique-Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale
InventorsYves HENROTIN, Cécile LAMBERT, Didier BORDERIE, François RANNOU
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Abstract
The present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of osteoarthritis. Further, the present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of rheumatic and musculoskeletal diseases (RMDs).
Claims10
1-12. (canceled)
A method of prevention and/or treatment of osteoarthritis comprising the administration of a subject in need thereof an effective dose of an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity as an active ingredient.
A method of prevention and/or treatment of rheumatic and musculoskeletal diseases (RMDs) comprising the administration of a subject in need thereof an effective dose of an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity as an active ingredient.
Dependencies are inferred from the claim text.