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US 2020/0347103 A1Published application
Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
AssigneeAgilent Technologies, Inc.
InventorsJørgen SCHØLLER, Liselotte BRIX, Henrik PEDERSEN, Tina JAKOBSEN
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Abstract
The present invention relates to MHC peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses thereof.
Claims11
An MHC multimer comprising (a-b-P)n, wherein n>1,
- wherein a and b together form a functional MHC protein capable of binding the peptide P,
- wherein (a-b-P) is the MHC-peptide complex formed when the peptide P binds to the functional MHC protein, and
- wherein each MHC peptide complex of a MHC multimer is associated with one or more multimerization domains,
- wherein in at least one MHC-peptide complex, the sequence of P originates from a Mycobacteria tuberculosis (TB) antigen.
1 more element
Dependencies are inferred from the claim text.