Substituted pyridazinone compound
AssigneeShenzhen TargetRx, Inc.
InventorsYihan Wang, Zhiqiang Liu
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Abstract
The present invention relates to a pharmaceutical composition of a substituted pyridazinone compound and use thereof. The substituted pyridazinone compound is a compound as represented by formula (I), or a pharmaceutically acceptable salt, a prodrug, a hydrate or solvent compound, a crystalline form, and a stereoisomer or isotopic variant thereof. The compound is a THR-beta agonist which can be used for treating and/or preventing diseases regulated by thyroid hormone analogues.
Claims12
A compound of formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, crystal form, stereoisomer or isotopic variant thereof:
- wherein,
- R1, R2, R3 and R4 are independently selected from hydrogen and deuterium;
- X1 and X2 are independently selected from CH3, CD3, CHD2 and CH2D;
- with the proviso that if X1 and X2 are both CH3, then at least one of R1, R2, R3 and R4 is deuterium.
Dependencies are inferred from the claim text.