Novel usp7 inhibitors for treating multiple myeloma

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, —OH, —NO2, —NH2, CN, —NR7C(═O)alkyl, —C(═O)NR7alkyl, or —NR7R8, wherein each alkyl is independently optionally substituted with one or more R9;
• R2 is H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, —OH, —NH2, —NO2, CN, —NR7C(═O)alkyl, —C(═O)NR7alkyl, or —NR7R8, wherein each alkyl is independently optionally substituted with one or more R9;
• R3 is H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, —OH, —NH2, —NO2, CN, —NR7C(═O)alkyl, —C(═O)NR7alkyl, or —NR7R8;
• wherein each alkyl is independently optionally substituted with one or more R9;
• R4 is H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, —OH, —NO2, —NH2, CN, —NR7C(═O)alkyl, —C(═O)NR7alkyl, or —NR7R8;
• wherein each alkyl is independently optionally substituted with one or more R9;
• wherein R1, R2, R3 and R4 are not simultaneously H;
• R5 is H, halogen, —CN, —OR7, or —NR7R8;
• R6 is alkyl, —C(═O)R10, —C(═S)R10, —C(O)NR7R8, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein the cycloalkyl, heterocycloalkyl, aryl, heteroaryl are each independently optionally substituted with one or more R11;
• and wherein the alkyl is substituted with one or more R12;
• each R7 and R8 is independently H, acyl, alkylacyl, alkenyl, alkenylacyl, or alkyl;
• each R9 is independently at each occurrence azido, —NR7R8, alkoxy, —(OCH2CH2)malkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein the alkyl and alkoxy are each independently optionally substituted with one or more substituents selected from alkoxy, haloalkoxy, halogen, and —OH;
• and wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more substituents selected from alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, —N3, and —OH;
• R10 is alkyl, alkenyl, alkynyl, —NR7R8, cycloalkyl, heterocycloalkyl, aryl, amino, heteroalkyl, alkylamino, aminoalkyl or heteroaryl, wherein the alkyl, alkenyl, and alkynyl are each independently optionally substituted with one or more R13;
• and wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more R12;
• each R11 is independently at each occurrence alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, —NO2, or —OH;
• each R12 is independently at each occurrence aryl or heteroaryl, wherein the aryl and heteroaryl are each independently optionally substituted with one or more substituents selected from alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, and —OH;
• each R13 is independently at each occurrence —OH, alkoxy, heteroalkyl, aryloxy, —NH2, arylalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —O-heteroaryl, —NR7aryl, —NR7heteroaryl, or —NR7C(═O)R14, wherein the cycloalkyl, heterocycloalkyl, aryl, heteroalkyl, and heteroaryl are each independently optionally substituted with one or more substituents selected from alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, —NO2, and —OH;
• R14 is alkyl, haloalkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, or heteroaryl, wherein the aryl and heteroaryl are each independently optionally substituted with one or more R15;
• and wherein the alkyl, alkenyl, and alkynyl are each independently optionally substituted with one or more substituents selected from halogen and —OH;
• each R15 is independently at each occurrence halogen, alkyl, CN, —C(═O)alkyl, or —C(═O)alkenyl, wherein the alkyl and alkenyl is each independently substituted with one or more substituents selected from halogen and —OH;
• m is 1, 2, or 3;
• and
• n is 0 or 1;
• provided that:
• (i) if R2 is —NO2, —NHC(O)Me or —NH2, and R1, R2, and R4 are each H;
• or R1 is Me and R2, R3, and R4 are each H;
• then R6 is not —C(O)R10 where R10 is —(CH2)—(CHMe)-phenyl;
• (ii) when R2 is Cl, R1, R3 and R4 are each H, R6 is —C(═O)R10, and R10 is (C2-C3)alkyl substituted with one R13;
• then R13 is not unsubstituted cyclopentyl, unsubstituted phenyl or unsubstituted 2-thiophenyl;
• and
• (iii) when R2 is Cl, and R1, R3 and R4 are each H;
• then R6 is —C(═O)R10, R10 is not 1-ethylpropyl.