Compounds with antimicrobial activity
AssigneesThe Hong Kong Polytechnic University, The Chinese University of Hong Kong
InventorsCong MA, Xiao YANG
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Abstract
This invention relates to compounds of formula 1, 2 or 3 a pharmaceutically acceptable salt, or solvate thereof, wherein X1, Y, R1, R2, R3, R4, and R5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.
Claims17
A compound of formula 1,
- a pharmaceutically acceptable salt, or a solvate thereof, wherein:
- (1) X1 is selected from the group consisting of —N═CH—, —CH═N—, —CH═CH—, —NH—CH2—, —CH2—NH—, —CH2—CH2—, —CH2—O—, —O—CH2—, —CH2—S—, —S—CH2— —S(═O)—CH2—, S(═O)—NH—, —NH—, —CH2—S(═O)—, —NH—S(═O)—, —S(═O)2—CH2—, —S(═O)2—NH—, —CH2—S(═O)2—, —NH—S(═O)—, —C(═O)—NH—, —NH—C(═O)—, and —C(═O)—;
- and
- (2) Each of R1-R5 is independently selected from the group consisting of hydrogen, hydroxy, nitro, acetyl, methyl, ethynyl, carboxy, carboxymethyl hydroxymethyl, methoxy, methoxycarbonyl, amninosulfonyl, aminocarbonyl, cyano, tetrazolyl, dimethylaminosulfonylaminocarbonyl, cyanomethyl, acetylaminosulfonyl, methoxyaminocarbonyi, methylsulfonylaminocarbonyl, t-butyl, fluoro, chloro, bromo, phenyl, trifluoromethyl and benzo;
- or
- wherein said compound is selected from the group consisting of:
A compound of formula 2,
- a pharmaceutically acceptable salt, or a solvate thereof, wherein:
- (1) X1 is selected from the group consisting of —N═CH—, —CH═N—, —CH═CH—, —NH—CH2—, —CH2—NH—, —CH2—CH2—, —CH2—O—, —O—CH2—, —CH2—S—, —S—CH2—, —S(═O)—CH2—, —S(═O)—NH—, —CH2—S(═O)—, —NH—S(═O)—, —S(═O)2—CH2—, —S(═O)2—NH—, —CH2O—S(═O)2—, —NH—S(═O)2—, —C(═O)—NH—, —NH—C(═O)—, and —C(═O)—;
- and
- (2) Each of R1-R5 is independently selected from the group consisting of hydrogen, hydroxy, nitro, acetyl, methyl, ethynyl, carboxy, carboxymethyl hydroxymethyl, methoxy, methoxycarbonyl, aminosulfonyl, aminocarbonyl, cyano, tetrazolyl, dimethylaminosulfonylaminocarbonyl, cyanomethyl, acetylaminosulfonyl, methoxyaminocarbonyl, methylsulfonylaminocarbonyl, t-butyl, fluoro, chloro, bromo, phenyl, trifluoromethyl and benzo.
A compound of formula
- a pharmaceutically acceptable salt, or a solvate thereof, wherein:
- (1) each of X1 and Y is independently selected from the group consisting of —NH—, —CH2—, —O—, and —S—;
- and
- (2) each of R1-R5 is independently selected from the group consisting of hydrogen, hydroxy, nitro, acetyl, methyl, ethynyl, carboxy, carboxymethyl hydroxymethyl, methoxy, methoxycarbonyl, aminosulfonyl, aminocarbonyl, cyano, tetrazolyl, dimethylaminosulfonylaminocarbonyl, cyanomethyl, acetylaminosulfonyl, methoxyaminocarbonyl, methylsulfonylaminocarbonyl, t-butyl, fluoro, chloro, bromo, phenyl, trifluoromethyl and benzo.
Dependencies are inferred from the claim text.