Systems, methods and apparatus for steering of energy deposition in a deep regional hyperthermia
OwnerCharles Anderson, Anna-Maria Ilisiuinventors
Life of this patent
Estimating the term…
Abstract
The present invention provides, inter alia, apparatus and systems for generating multiple H-fields to additively combine and control deep E-field generation resulting in clinically acceptable centralized heating, and methods for inducing locoregional hyperthermia in a subject using the same. The methods, systems and apparatus disclosed herein provide improved hyperthermia treatment to subjects in need thereof, such as, for example, subjects suffering from cancer.
Claims22
A system for generating multiple H-fields to additively combine and control deep E-field generation resulting in clinically acceptable centralized heating, comprising:
- a) a base of sufficient dimensions to accommodate a subject;
- b) one or more sectors, wherein:
- i. each sector comprises at least one pair of coils, wherein each coil of the pair is substantially parallel to and faces the other coil and each coil of the pair is separated by a distance;
- ii. each coil of the pair is arranged in a predetermined design;
- and
- iii. the width of each coil is equal to or greater than the separation distance between each coil pairs;
- and
- c) one or more radio-frequency (RF) generators to control the amplitude of RF applied on each coil of the pair to move the Specific Absorption Rate (SAR) pattern in the desired direction.
A method for inducing locoregional hyperthermia in a subject in need thereof, comprising:
- a) providing an apparatus for generating multiple H-fields to additively combine and control deep E-field generation, the apparatus comprising:
- (I) a base to accommodate the subject;
- (II) one or more sectors, wherein:
- i. each sector comprises at least one pair of coils, wherein each coil of the pair is substantially parallel to and faces the other coil and each coil of the pair is separated by a distance;
- ii. each coil of the pair is arranged in a predetermined design;
- and
- iii. the width of each coil is equal to or greater than the separation distance between each coil pairs;
- and
- (III) one or more radio-frequency (RF) generators to control the amplitude of RF applied on each coil of the pair to move the Specific Absorption Rate (SAR) pattern in the desired direction;
- b) adjusting the size of coils in each sector and the size of the base based on the size of the subject and the desired depth of heating;
- c) placing the subject on the base;
- and
- d) generating multiple H-fields to create targeted heating at the desired depth in the subject.
A system for generating multiple H-fields to additively combine and control deep E-field generation resulting in clinically acceptable centralized heating, comprising:
- a) an interchangeable base;
- b) one or more sectors, wherein:
- i. each sector comprises at least one pair of coils, wherein each coil of the pair is substantially parallel to and faces the other coil and each coil of the pair is separated by a distance;
- ii. each coil of the pair is arranged in a predetermined design;
- iii. the width of each coil is equal to or greater than the separation distance between each coil pairs;
- and
- iv. the length of each coil is equal to or greater than 1.5 times the separation distance between each coil pairs;
- c) one or more radio-frequency (RF) generators to control the amplitude of RF applied on each coil of the pair to move the Specific Absorption Rate (SAR) pattern in the desired direction
- d) a solid-state switch;
- e) an air-cooling setup;
- and optionally
- f) an MRTI setup.
An apparatus substantially as disclosed in FIGS. 1 to 5B.
A system substantially as disclosed in FIG. 5A.
Dependencies are inferred from the claim text.