Systems and methods to improve sleep disordered breathing using closed-loop feedback

A system comprising:

• a sensor implantable adjacent to an anterior lingual muscle and configured to record physiological data;
• a computing device comprising:
• a non-transitory memory storing instructions;
• and
• a processor to access the non-transitory memory and execute the instructions to at least:
• monitor the physiological data recorded by the sensor;
• identify a trigger within the physiological data, wherein the trigger is identified as a biomarker for a condition related to sleep;
• and
• apply a rule-based classification to the trigger to determine whether one or more parameters of a stimulation should be altered based on the biomarker, wherein the rule-based classification is adaptive;
• an electrode implantable adjacent to a hypoglossal nerve and configured to deliver the stimulation to the hypoglossal nerve during a period and to alter the one or more parameters of the stimulation in response to a signal from the computing device.