Normalization of blood pressure with spinal cord epidural stimulation
OwnerSusan J. Harkema, Claudia Angeli +1inventors
InventorsSusan J. Harkema, Claudia Angeli, Yangsheng Chen
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Abstract
Methods for normalization of blood pressure for individuals with spinal cord injuries include providing such individuals with spinal cord electrical stimulation optimized for cardiovascular function. An electrode array provides specific stimulation configurations identified to maintain systolic blood pressure within targeted normative ranges without skeletal muscle activity.
Claims19
A method for controlling blood pressure comprising:
- providing an electrode array comprising a plurality of electrodes, wherein at least one of the plurality of electrodes is configured to deliver electrical stimulation to an individual;
- determining, for the individual, a configuration of electrical stimulation delivered by the electrode array effective in modifying a blood pressure of the individual;
- and
- delivering electrical stimulation to the individual, via the electrode array, according to the configuration.
A method of creating an electrical stimulation configuration for controlling an individual's blood pressure via electrical stimulation, the method comprising:
- defining, for an individual having an implanted electrode array in operative engagement with the individual's spinal cord, a normalized blood pressure range and a baseline blood pressure, wherein the baseline blood pressure is outside the normalized blood pressure range;
- providing electrical stimulation to the individual using different combinations of electrodes in the electrode array;
- identifying at least one combination of electrodes which, when electrical stimulation is provided via the at least one combination of electrodes, modify the individual's blood pressure without producing a motor function in the individual;
- determining, for the identified combinations of electrodes, a frequency and amplitude of electrical stimulation effective in shifting the individual's blood pressure from the baseline blood pressure to the normalized blood pressure range;
- and
- defining the electrical stimulation configuration according to the at least one identified combinations of electrodes, the frequency, and the amplitude.
A method for increasing blood pressure in an individual, the method comprising delivering to the individual an effective spinal cord epidural stimulation.
The system for normalizing blood pressure in an individual with spinal cord injury, the system comprising an implantable electrode array, a pulse generator, and instructions for using the implantable electrode array and the pulse generator to normalize blood pressure.
Dependencies are inferred from the claim text.