Microneedle for local delivery of therapeutic agent
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAnil K. Lalwani, Jeffrey W. Kysar, Aykut Aksit, Daniel N. Arteaga
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Abstract
The disclosed subject matter relates to a cleavable microneedle for delivery of therapeutic agent, wherein the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent. The microneedle may be configured to administer the therapeutic agent to the inner ear of a subject. Also disclosed is a method for preparing a microneedle using two-photon polymerization lithography.
Claims33
A microneedle comprising a longitudinal body, said body having a detachable portion, wherein the detachable portion comprises therapeutic agent.
A method for preparing a microneedle or a microneedle array comprising one or a plurality of microneedles on a base, the method comprising
- designing a microneedle configured to penetrate a membrane with a rupture force of from 0.4 to 5 milliNewtons;
- configuring a two-photon polymerization lithography apparatus to fabricate the microneedle or microneedle array on a base according to the design;
- and
- operating the two-photon polymerization lithography apparatus to prepare the microneedle or microneedle array.
Dependencies are inferred from the claim text.