Medical Devices for Delivery of siRNA
AssigneeSorrento Therapeutics, Inc.
InventorRussell Frederick Ross
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Abstract
Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.
Claims18
A device for delivery of an siRNA construct across a dermal barrier, the device comprising:
- a microneedle and a plurality of nanostructures fabricated on a surface of the microneedle, the nanostructures being arranged in a predetermined pattern;
- and
- an siRNA construct in fluid communication with the microneedle.
A method for delivering an siRNA construct across a dermal barrier, the method comprising:
- penetrating the stratum corneum with a microneedle having a surface on which a plurality of nanostructures are fabricated in a predetermined pattern, wherein the microneedle further contains a channel;
- transporting an siRNA construct from a reservoir through the channel of the microneedle and across the stratum corneum.
18-23. (canceled)
Dependencies are inferred from the claim text.