Inhaler system

A method for determining a probability of an asthma exacerbation in a subject, the method comprising:

• receiving one or more rescue inhalation airflow parameters, each of the one or more rescue inhalation airflow parameters being associated with a respective rescue inhalation;
• determining a number of rescue inhalations performed during a first time period based on the received one or more rescue inhalation airflow parameters;
• and
• determining, based at least on a weighted model, the probability of the asthma exacerbation based on the determined number of rescue inhalations and the received one or more rescue inhalation airflow parameters, wherein a weight associated with the number of rescue inhalations is greater than a weight associated with received one or more rescue inhalation airflow parameters.

A method for demarcating a subpopulation of subjects in a population of subjects, the method comprising:

• receiving inhalation airflow parameters for each subject of the population of subjects, each of the rescue inhalation airflow parameters being associated with one or more respective rescue inhalations performed by each subject of the population of subjects;
• determining a number of rescue inhalations performed by each subject of the population of subjects during a first time period;
• and
• determining, based at least on a weighted model associated with each subject, a probability of an asthma exacerbation for each subject based on the determined number of rescue inhalations performed by each subject and the received inhalation airflow parameters for each subject, wherein a weight associated with the number of rescue inhalations is greater than a weight associated with received inhalation airflow parameters for each subject;
• determining a threshold probability of asthma exacerbations based on the probability of the asthma exacerbation for each subject;
• and
• demarcating the subpopulation of subjects from population of subjects using the threshold probability of asthma exacerbations.

A computer-readable medium having stored thereon instructions that, when executed by a control circuit, cause the control circuit to:

• receive one or more rescue inhalation airflow parameters, each of the one or more rescue inhalation airflow parameters being associated with a respective rescue inhalation;
• determine a number of rescue inhalations performed during a first time period based on the received one or more rescue inhalation airflow parameters;
• and
• determine, based at least on a weighted model, the probability of the asthma exacerbation based on the determined number of rescue inhalations and the received one or more rescue inhalation airflow parameters, wherein a weight associated with the number of rescue inhalations is greater than a weight associated with received one or more rescue inhalation airflow parameters.