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US 2020/0345902 A1Published application
Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
AssigneeBIOTRONIK SE & Co. KG
InventorsRonald E. Betts, John Dang Nguyen, Beatris Flores
Life of this patent
Estimating the term…
Abstract
A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n—X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
Claims3
A pharmaceutical formulation comprising ethanol and 1-60 weight percent of a 40-O-cyclic hydrocarbon ester compound having the structure:
- where R is C(O)—(CH2)n—X, n is 0, 1 or 2, X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, one or more linear-chain or cyclic carbon atoms may contain an OH or halide substitution, and the rapamycin parent structure may contain substitutions at non-40 positions.
Dependencies are inferred from the claim text.