Absorbable permeability-modulated barrier composites and applications thereof
AssigneePoly-Med, Inc.
InventorShalaby W. Shalaby
Life of this patent
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Abstract
Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
Claims20
1-13. (canceled)
An absorbable, permeability-modulated barrier composite comprising, at least a first component, and one or both of a component comprising a mesh or an electrostatically spun, non-woven microfibrous fabric;
- wherein the first component comprises a flexible film comprising a synthetic absorbable polymer comprising
- a) a polyaxial copolyester derived from at least two monomers of glycolide, lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one or a morpholinedione;
- b) a polyether ester derived from a polyether-glycol that is grafted with at least one monomer of glycolide, lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one or a morpholinedione;
- or
- c) a polyether-ester-urethane derived from a polyether-glycol that is grafted with at least one monomer of glycolide, lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one or a morpholinedione, to form a polyether ester glycol, where the polyether ester glycol is interconnected by urethane linkages formed through the reaction of said polyether ester glycol with an aliphatic diisocyanate;
- wherein the knitted mesh component comprises
- a) an absorbable block copolymer comprising a block derived only from trimethylene carbonate and terminal segments derived from glycolide;
- or
- b) a warp-knitted construction comprising a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, l-lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione;
- and
- wherein the electrostatically spun, non-woven microfibrous fabric comprises,
- a) a polyaxial copolyester derived from at least two monomers of glycolide, l-lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, or a morpholinedione;
- or
- b) a polyether-ester derived from a polyether-glycol grafted with at least one monomer of glycolide, l-lactide, E-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, or a morpholinedione;
- and optionally, wherein at least one of the components comprises a hydroswellable polymer.
The barrier of claim 21, wherein at least one of the components further comprises at least one bioactive agent.
Dependencies are inferred from the claim text.