Extracellular matrix and its use for regulating the differentiation of mesenchymal stem cells
AssigneeConsejo Superior De Investigaciones Cientificas (Csic)
InventorsFernando RODRÍGUEZ PASCUAL, Tamara ROSELL GARCÍA
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Abstract
The present invention relates to an extracellular matrix comprising ECM producer cells, a lysyloxidase (LOX), and bone morphogenetic protein-1 (BMP1), and its use for regulating the differentiation of mesenchymal stem cells and increasing the synthesis and/or deposit of collagen in an extracellular matrix. The present invention also relates to a method for obtaining said extracellular matrix comprising incubating cells in the presence of a composition comprising a lysyl oxidase, or a fragment thereof, and bone morphogenetic protein-1, or a fragment thereof.
Claims24
An extracellular matrix (ECM) comprising a lysyl oxidase (LOX), or a fragment thereof, and bone morphogenetic protein-1 (BMP 1), or a fragment thereof.
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A method for increasing the deposit of collagen in an extracellular matrix (ECM) comprising cultivating ECM producer cells in the presence of a composition comprising a lysyl oxidase (LOX) and bone morphogenetic protein-1 (BMP1), or culturing ECM producer cells genetically modified for producing the LOX enzyme and/or BMP 1.
Dependencies are inferred from the claim text.