Biocompatible hydrogel compositions and uses thereof
AssigneeOttawa Heart Institute Research Corporation
InventorsMarc Ruel, Erik Suuronen, Emilio Alarcon
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Abstract
Provided herein are biocompatible and/or biodegradable hydrogel compositions comprising native collagen and chondroitin sulfate, the collagen and chondroitin sulfate being chemically cross-linked thereby forming a matrix. The native collagen may comprise recombinant human collagen type I (rHCI), recombinant human collagen type III (rHCIII), or a combination thereof, for example. Methods and uses thereof for regeneration or repair of tissue, improvement of tissue function, mechanical stabilization of tissue, prevention of tissue damage, or prevention of tissue loss of function are described, particularly with respect to cardiac tissue and myocardial infarction events.
Claims51
A biocompatible and/or biodegradable hydrogel composition comprising native collagen and chondroitin sulfate, the collagen and chondroitin sulfate being at least partially chemically cross-linked thereby forming a matrix, wherein the native collagen is recombinant human collagen type I (fHCI), recombinant human collagen type III (rHCIII), or a combination thereof.
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The method according to claim wherein the hydrogel composition is administered by injection to the heart following a myocardial infarction or ischemic event.
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Dependencies are inferred from the claim text.