Method Of Corneal Transplantation Or Corneal Inlay Implantation With Cross-Linking

A method of corneal implantation with cross-linking, said method comprising the steps of:

• prior to implantation, treating an implant formed from donor corneal tissue or a tissue culture grown corneal stroma with a solution of sodium dodecyl sulfate (SDS), Triton X-100, benzalkonium chloride (BAK), Igepal, genipin, 100% glycerol, or alcohol for making the implant acellular, and for killing any bacteria, viruses, or parasites prior to implantation;
• implanting the implant into a recipient cornea of an eye of a patient so as to overlie stromal tissue of the recipient cornea;
• before or after implantation, applying laser energy to the implant so as to modify the refractive power of the implant while being monitored using a Shack-Hartmann wavefront system so as to achieve a desired refractive power for the implant;
• and
• before or after implantation, applying a cross-linking solution that includes a photosensitizer to the implant, and irradiating the implant so as to activate cross-linkers in the implant, and thereby cross-link the implant to prevent an immune response to the implant and/or rejection of the implant by the patient.