Scalable three-dimensional elastic construct manufacturing
AssigneeAllergan Pharmaceuticals International Limited
InventorsAnthony Steven WEISS, Suzanne Marie MITHIEUX
Life of this patent
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Abstract
Tissue repair and restoration can be performed using an elastic material formed from tropoelastin. The elastic material can be formed by providing a solution of tropoelastin monomers, applying the solution to a surface, and heating the solution on the surface in absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form an elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution.
Claims18
A method for forming an elastic material, including:
- applying tropoelastin monomers to a surface;
- and
- heating the tropoelastin monomers on the surface to a temperature of from about 60° C. to about 200° C. at a pH of less than 8.5 and in the absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form an elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution, wherein the elastic material is hard and glassy.
A method for forming an elastic material, the method comprising:
- applying tropoelastin monomers to a surface;
- and
- heating the tropoelastin monomers on the surface to a temperature of from about 60° C. to about 200° C. in the absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form a hard, elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution.
A method for forming an elastic material, the method comprising:
- applying tropoelastin monomers to a surface;
- and
- heating the tropoelastin monomers on the surface to a temperature of from about 60° C. to about 200° C. in the absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form a glassy, elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution.
A method for forming an elastic material, the method comprising:
- applying tropoelastin monomers to a surface;
- and
- heating the tropoelastin monomers on the surface to a temperature of from about 60° C. to about 200° C. in the absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form a glassy, elastic material that does not substantially dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution.
Dependencies are inferred from the claim text.