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US 2020/0345869 A1Published application
Microbubble tether for diagnostic and therapeutic applications
AssigneeGeneral Electric Company
InventorsMatthew David BUTTS, Jason William CASTLE, Andrew Soliz TORRES, Jeannette Christine ROBERTS, Binil Itty Ipe KANDAPALLIL
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Abstract
The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
Claims7
1-11. (canceled)
An ultrasound-based treatment method, comprising:
- introducing an albumin microbubble composition into a patient, wherein the albumin microbubble composition comprises:
- an albumin shell, a molecule of interest, and a moiety binding the molecule of interest to the albumin shell, wherein the moiety preferentially binds to the albumin shell relative to free, native human serum albumin;
- and
- directing ultrasonic energy at an anatomic region of interest to cause cavitation of the albumin microbubbles at the anatomic region of interest.
1 more element
Dependencies are inferred from the claim text.