Non-metallic magnetic resonance contrast agent
AssigneeHadasit Medical Research Services and Development Ltd.
InventorsAyelet GAMLIEL, Talia HARRIS, Gal SAPIR, Jacob SOSNA, Moshe John GOMORI, Rachel KATZ-BRULL
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Abstract
The present application provides a compound comprising at least one isotopically labeled nitrogen atom for use in diagnosing a condition or disease in a subject, compositions and kits comprising the compound and methods of using the same.
Claims21
1-51. (canceled)
A method of diagnosis a condition or disease in a subject, the method comprising administrating to the subject a diagnostically effective amount of at least one hyperpolarized labeled compound comprising at least one isotopically labeled nitrogen atom and monitoring a signal from the hyperpolarized compound in the subject, to thereby diagnose the condition or disease in the subject, optionally the signal is monitored by magnetic resonance techniques.
A compound being [15N]glycerophosphocholine, optionally comprising at least one labeled hydrogen atom.
A compound comprising at least one isotopically labeled nitrogen atom, wherein the compound is in a hyperpolarized state and wherein the compound is at least one of an amine, an amide, an imide, a nitrogen-containing ion or an amino acid, optionally the compound is nitrate or urea.
Dependencies are inferred from the claim text.