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US 2020/0345864 A1Published application
Compositions and methods for enhancing transport through mucus
AssigneeThe Johns Hopkins University
InventorsJustin Hanes, Samuel K. Lai
Life of this patent
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Abstract
The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.
Claims14
1-76. (canceled)
A method for diagnosing a condition in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising
- (a) a plurality of particles, each particle comprising:
- (i) a pharmaceutically acceptable polymer core;
- and
- (ii) a polyethylene glycol) (PEG) having a molecular weight of about 300 Da, about 600 Da, or about 1 kDa disposed on the outer surface of the polymer core by covalent linkage,
- wherein the particle has a particle size between 150 nm and 750 nm in diameter;
- (b) an imaging agent, wherein the imaging agent is
- (i) disposed on or coated on the surface of the pharmaceutically acceptable polymer core or the PEG;
- or
- (ii) covalently attached to the pharmaceutically acceptable polymer core or the PEG;
- and
- (c) one or more pharmaceutically acceptable excipients or carriers.
8 more elements
Dependencies are inferred from the claim text.