Transition metal-based functional moieties for preparing cell targeting conjugates
AssigneeLinXis B.V.
InventorsEugen Merkul, Niels Jurriaan Sijbrandi, Joey Armand Muns, Augustinus Antonius Maria Silvester Van Dongen, Paulus Johannes Gerardus Maria Steverink, Hendrik Jan Houthoff
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Abstract
The disclosure relates to secondary functional moieties comprising a transition metal-based linker and a primary functional moiety bound thereto. The disclosure also relates to cell targeting conjugates comprising a linker of the invention. The disclosure further relates to a medicament comprising the cell targeting conjugate and to the use of the cell targeting conjugates in the diagnosis and treatment of cancer.
Claims19
A secondary functional moiety according to formula I
- wherein
- M is a transition metal complex,
- one of the ligands L1 or L2 is iodide, bromide, or chloride and the other ligand is a primary functional moiety;
- Nu is a nucleophilic group, wherein Nu1 and Nu2 can be the same groups or different groups and which together form a bidentate ligand, with the proviso that the bidentate ligand is not ethane-1,2-diamine.
A method of treating a mammalian subject for cancer, the method comprising:
- utilizing the cell targeting conjugate to treat the subject.
Dependencies are inferred from the claim text.