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US 2020/0345861 A1Published application
Pyrrolobenzodiazepine-antibody conjugates
AssigneeMedImmune, LLC
InventorsPATRICIUS HENDRIKUS CORNELIS VAN BERKEL, PHILIP WILSON HOWARD
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Abstract
Conjugates of an antibody that binds to CD19 with PBD dimers.
Claims22
-115. (canceled)
A method of treating lymphoma or leukemia comprising administering to a patient a conjugate of formula ConjA:
- ConjB:
- ConjC:
- ConjD:
- or ConjE:
- wherein Ab is an antibody that binds to CD19, the antibody comprising a VH domain having the amino acid sequence according to SEQ ID NO. 2;
- and
- wherein the drug loading is an integer from 1 to 8.
4 more elements
Dependencies are inferred from the claim text.