Uses of amphiphiles in immune cell therapy and compositions therefor
AssigneeMassachusetts Institute of Technology
InventorsDarrell J. IRVINE, Peter C. DEMUTH
Life of this patent
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Abstract
Provided herein are methods for stimulating an immune response to a target cell population or a target tissue in a subject by administering to the subject a composition comprising an amphiphilic ligand conjugate. Such an amphiphilic ligand conjugate can comprise a lipid, one or more cargos (e.g., a CAR ligand, a chimeric cytokine receptor target, a chimeric co-stimulation receptor target, a synNotch receptor target), and optionally a linker.
Claims55
A method of stimulating an immune response to a target cell population or a target tissue in a subject, the method comprising administering a composition to the subject, wherein the composition comprises an amphiphilic ligand conjugate comprising a lipid, a chimeric antigen receptor (CAR) ligand, and optionally a linker, and wherein the subject comprises an immune cell comprising a CAR, wherein the immune cell is not a T cell.
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A method of stimulating an immune response to a target cell population or a target tissue in a subject, the method comprising administering to the subject a composition, wherein the composition comprises an amphiphilic ligand conjugate comprising a lipid, a first chimeric cytokine receptor target, optionally a second chimeric cytokine receptor target, and optionally a linker, and wherein the subject comprises an immune cell comprising a chimeric cytokine receptor.
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A method of stimulating an immune response to a target cell population or a target tissue in a subject, the method comprising administering to the subject a composition, wherein the composition comprises an amphiphilic ligand conjugate comprising a lipid, a first chimeric co-stimulation receptor target, optionally a second chimeric co-stimulation receptor target, and optionally a linker, and wherein the subject comprises an immune cell comprising a chimeric co-stimulation receptor.
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A method of stimulating an immune response to a target cell population or a target tissue in a subject, the method comprising administering to the subject a composition, wherein the composition comprises an amphiphilic ligand conjugate comprising a lipid, a synthetic Notch (synNotch) receptor target, and optionally a linker, and wherein the subject comprises an immune cell comprising a synNotch receptor.
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An amphiphilic ligand conjugate comprising a lipid, a first ligand, a second ligand, and optionally a linker.
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Dependencies are inferred from the claim text.