Lyophilized preparation of cytotoxic dipeptides
AssigneeOncopeptides AB
InventorsJack SPIRA, Fredrik LEHMANN
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Abstract
The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; β-cyclodextrin; ocyclodextrin; hydroxypropyl-β-cyclodextrin; sulfobutylether-β-cyclodextrin; lactose; benzyl alcohol; diso dium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.
Claims22
1-40. (canceled)
A method for treating multiple myeloma, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition prepared by directly dissolving a lyophilized pharmaceutical preparation comprising melphalan flufenamide or a pharmaceutically acceptable salt thereof and sucrose in a physiologically acceptable aqueous solution.
A method for treating multiple myeloma, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition prepared by directly dissolving a lyophilized pharmaceutical preparation comprising melphalan flufenamide hydrochloride (J1) and sucrose in a physiologically acceptable aqueous solution.
Dependencies are inferred from the claim text.