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US 2020/0345846 A1Published application
Corrole compositions
AssigneeTechnion Research & Development Foundation Limited
InventorsZeev GROSS, Matan SOLL
Life of this patent
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Abstract
Embodiments of the invention relate to compositions comprising a corrole and optionally a protein, wherein the composition are characterized by improved water solubility. The corrole may be a hydrophobic corrole, according to formula [I]. The protein may be a plasma protein. The plasma protein may be albumin. The compositions may be in nanoparticulate form.
Claims26
A composition comprising:
- a corrole according to formula [I];
- wherein R1 through R8 are each independently H, halogen, CHO, C1-C4 alkyl or halogenated alkyl;
- R9 through R11 are each independently H, straight or branched C1-C12 alkyl, C6-C12 aralkyl, C6-C12 aryl, or C6-C12 heteroaryl, having an oxygen or nitrogen atom as a heteroatom, wherein each of straight or branched C1-C12 alkyl, C6-C12 aralkyl, C6-C12 aryl, or C6-C12 heteroaryl may be unsubstituted or substituted by a halogen or by an amino group;
- L, may be present or absent, if present is halogen, an oxo group, a hydroxyl group, acetonitrile, dimethylsulfoxide, dimethylformamide, a pyridine group or a water molecule;
- and
- M is H or an atom from group 3-15 or an f-block element;
- and
- a protein non-covalently conjugated to the corrole, the composition having the form of nanoparticles, wherein at least 50% of said particles have a mean diameter size in the range of 30 nm to 200 nm.
5 more elements
7-8. (canceled)
(canceled)
-17. (canceled)
19-24. (canceled)
(canceled)
31-35. (canceled)
Dependencies are inferred from the claim text.