Vaccines against genital herpes simplex infections
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorKonstantin G. Kousoulas
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Abstract
The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.
Claims25
A vaccine for treating or preventing a herpes simplex virus (HSV) infection, the vaccine comprising a recombinant HSV, wherein the recombinant HSV comprises a recombinant HSV genome comprising at least one modification in each of the UL53 and UL20 genes and wherein the recombinant HSV is capable of replication in a host cell and incapable of entry into axonal compartments of neurons.
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An recombinant herpes simplex virus (HSV) genome comprising at least one modification in each of the UL53 and UL20 genes and wherein a virus comprising the genome is capable of replication in a host cell and incapable of entry into axonal compartments of neurons.
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Dependencies are inferred from the claim text.