Viral vectors and their use in therapeutic methods
AssigneesThe General Hospital Corporation, Georgetown University, Catherex, Inc.
InventorsPaul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
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Abstract
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
Claims15
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A method of treating metastatic cancer in a patient, said method comprising administering to said patient having metastatic cancer a herpes simplex virus (HSV-1) comprising an inactivating mutation in the ICP47 locus of said herpes virus that results in early expression of US11, and an inactivating mutation in the γ34.5 neurovirulence locus of said virus.
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Dependencies are inferred from the claim text.